The objective of present investigation was to study and evaluate the individual and combined effects of solubilizers on drug release from pioglitazone controlled release matrix tablets. Controlled release matrix tablets of pioglitazone were developed for better control of blood glucose levels by prolonging its duration of action and to reduce GI disturbances with improved patient compliance. The tablets were prepared by wet granulation technique employing 50% w/w Hydroxy propyl methyl cellulose K-15M as release controlling agent. Polyvinyl pyrrolidone and polyethylene glycol 6000 at 2% w/w were used as solubilizers to study the individual and combined effects of solubilizers on drug release from pioglitazone matrix tablets. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. All Pioglitazone matrix tablets followed first order, Higuchi drug release kinetics with diffusion as the dominant mechanism of drug release. As per Korsmeyer-Peppas equation, the release exponent ''n'' ranged 0.669-0.892 indicating that drug release from all the batches was by non-Fickian diffusion mechanism. Polyethylene glycol 6000 gave relatively higher release than polyvinyl pyrrolidone. A combination of Polyvinyl pyrrolidone and polyethylene glycol 6000 gave slow, controlled and complete release of pioglitazone over 24 hours.
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